Cancer cachexia prevention via physical exercise: molecular mechanisms

Journal of Cachexia, Sarcopenia and Muscle

Gould Douglas W.¹  Lahart Ian¹  Carmichael Amtul R.²  Koutedakis Yiannis¹ 

[1] School of Sport, Performing Arts and Leisure, Department of Physical Activity, Exercise and Health, University of Wolverhampton, Walsall, West Midlands;Department of Surgery, Dudley Group of Hospitals NHS Trust, Russell's Hall Hospital, Dudley, West Midlands

关键词: Exercise;    Physical activity;    Cachexia;    Muscle wasting;    Cancer;    Resistance training;    Aerobic training;    Inflammation;   

DOI  :  10.1007/s13539-012-0096-0

来源: Wiley

【 摘 要 】

Abstract

Cancer cachexia is a debilitating consequence of disease progression, characterised by the significant weight loss through the catabolism of both skeletal muscle and adipose tissue, leading to a reduced mobility and muscle function, fatigue, impaired quality of life and ultimately death occurring with 25–30 % total body weight loss. Degradation of proteins and decreased protein synthesis contributes to catabolism of skeletal muscle, while the loss of adipose tissue results mainly from enhanced lipolysis. These mechanisms appear to be at least, in part, mediated by systemic inflammation. Exercise, by virtue of its anti-inflammatory effect, is shown to be effective at counteracting the muscle catabolism by increasing protein synthesis and reducing protein degradation, thus successfully improving muscle strength, physical function and quality of life in patients with non-cancer-related cachexia. Therefore, by implementing appropriate exercise interventions upon diagnosis and at various stages of treatment, it may be possible to reverse protein degradation, while increasing protein synthesis and lean body mass, thus counteracting the wasting seen in cachexia.

【 授权许可】

CC BY-NC   
© 2013 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.