The role of insulin resistance in the development of muscle wasting during cancer cachexia

Journal of Cachexia, Sarcopenia and Muscle

Honors Mary A.¹ 

[1] Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, West Lafayette, IN

关键词: Insulin resistance;    Muscle wasting;    Cancer cachexia;    Animal models;   

DOI  :  10.1007/s13539-011-0051-5

来源: Wiley

【 摘 要 】

Abstract

Background

Cancer cachexia is a complex syndrome associated with multiple metabolic abnormalities. Insulin resistance is present in many cancer patients and may be one mechanism through which muscle wasting occurs.

Methods and results

The present review examines evidence in support of a role for insulin resistance in the development of muscle wasting during cancer cachexia and identifies areas for future research. Patients suffering from cancer cachexia tend to exhibit insulin resistance and improvements in insulin resistance have the potential to improve cachexia symptoms. In addition, evidence suggests that insulin resistance may occur prior to the onset of cachexia symptoms.

Conclusions

Further investigation of the role of insulin resistance in cancer cachexia is needed. The use of translational research in this area is strongly encouraged, and has important implications for clinical research and the treatment and prevention of cancer cachexia.

【 授权许可】

CC BY-NC   
© 2012 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.