Lack of predictive power of plasma lipids or lipoproteins for gestational diabetes mellitus in Japanese women

Journal of Diabetes Investigation

Yuko Iimura⁶  Masaaki Matsuura¹  Zemin Yao²  Satoru Ito⁴  Mutsunori Fujiwara³  Michiyasu Yoshitsugu⁶  Akito Miyauchi⁵ 

[1] Department of Cancer Genomics, Cancer Institute for JFCR, Tokyo, Japan;Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada;Department of Clinical Pathology, Japanese Red Cross Medical Center, Tokyo, Japan;Fujirebio Inc., Tokyo, Japan;Department of Obstetrics and Gynecology, Japanese Red Cross Medical Center, Tokyo, Japan;Department of Diabetes and Endocrinology, Japanese Red Cross Medical Center, Tokyo, Japan

关键词: Apolipoprotein C‐III;    Gestational diabetes mellitus;    Glucose challenge test;   

DOI  :  10.1111/jdi.12363

来源: Wiley

【 摘 要 】

Abstract

Aims/Introduction

To determine the diagnostic potential of plasma lipids and apolipoproteins in gestational diabetes mellitus (GDM), we carried out a retrospective cohort study of 1,161 Japanese women at 20–28 weeks of gestation who underwent a glucose challenge test (GCT).

Materials and Methods

A total of 1,161 Japanese women at 20–28 weeks of gestation underwent a GCT. Participants with a positive test (GCT[+]) underwent a subsequent oral glucose tolerance test. Clinical and biochemical parameters were determined and quantification of apolipoproteins (Apo), including ApoB, ApoB48, ApoA-I and ApoC-III, was carried out.

Results

The prevalence of GCT(+; with a 130 mg/dL glucose cut-off) and GDM was 20% and 4%, respectively. There was a trend for increased triglycerides and ApoC-III in GDM(+) participants. However, the difference in plasma triglycerides, ApoC-III or ApoB48 did not reach statistical significance between GDM(+) and GDM(−) women. Values of 1-h glucose (P < 0.001) and fasting glucose (P = 0.002) were significant risk factors for GDM.

Conclusions

Prediction of GDM using only the ApoC-III value is not easy, although triglycerides and ApoC-III were higher in the GDM(+) group. The present findings show no significant difference in plasma lipid levels between women diagnosed with GDM and those with normal glucose tolerance.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

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