Effects of chromium malate on glycometabolism, glycometabolism‐related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose–response and curative effects study

Journal of Diabetes Investigation

Weiwei Feng⁴  Guanghua Mao⁵  Qian Li⁴  Wei Wang⁴  Yao Chen⁵  Ting Zhao¹  Fang Li³  Ye Zou⁴  Huiyu Wu²  Liuqing Yang¹ 

[1] School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China;School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China;School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China;School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China;School of The Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China

关键词: Chromium malate;    Glycometabolism;    Lipid metabolism;   

DOI  :  10.1111/jdi.12350

来源: Wiley

【 摘 要 】

Abstract

Aims/Introduction

The present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats, and dose–response and curative effects.

Materials and Methods

The model of type 2 diabetes rats was developed, and daily treatment with chromium malate was given for 4 weeks. A rat enzyme-linked immunosorbent assay kit was used to assay glycometabolism, glycometabolism-related enzyme levels and lipid metabolism changes.

Results

The results showed that the antihyperglycemic activity increased with administration of chromium malate in a dose–dependent manner. The serum insulin level, insulin resistance index and C-peptide level of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly lower than that of the model, chromium trichloride and chromium picolinate groups. The hepatic glycogen, glucose-6-phosphate dehydrogenase and glucokinase levels of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly higher than that of the model, chromium trichloride and chromium picolinate groups. Chromium malate at a dose of 20.0 and 20.8 μg chromium/kg bodyweight significantly changed the total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides levels compared with the chromium trichloride and chromium picolinate groups.

Conclusions

The results showed that chromium malate exhibits greater benefits in treating type 2 diabetes, and the curative effect of chromium malate is superior to chromium trichloride and chromium picolinate.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

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