Corneal confocal microscopy: Recent progress in the evaluation of diabetic neuropathy

Journal of Diabetes Investigation

Nikolaos Papanas¹ 

[1] Diabetes Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece

关键词: Corneal confocal microscopy;    Diabetic polyneuropathy;    Small fibers;   

DOI  :  10.1111/jdi.12335

来源: Wiley

【 摘 要 】

Abstract

The present brief review discusses recent progress with corneal confocal microscopy for the evaluation of diabetic sensorimotor polyneuropathy. Corneal confocal microscopy is a new, non-invasive and reproducible diagnostic modality, and it can also be easily applied for patient follow up. It enables new perspectives of studying the natural history of diabetic sensorimotor polyneuropathy, severity of nerve fiber pathology and documenting early nerve fiber regeneration after therapeutic intervention. It shows moderate to high sensitivity and specificity for the timely diagnosis of diabetic sensorimotor polyneuropathy. Currently, corneal confocal microscopy is mainly used in specialized centers, but deserves more widespread application for the assessment of diabetic sensorimotor polyneuropathy. Finally, further progress is required in terms of technical improvements for automated nerve fiber quantification and for analysis of larger images.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.