Relationship and factors responsible for regulating fasting and post‐challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus

Journal of Diabetes Investigation

Sae Aoyama-Sasabe⁴  Xin Xin³  Ataru Taniguchi¹  Yoshikatsu Nakai⁵  Rie Mitsui⁹  Hideaki Tsuji²  Daisuke Yabe⁸  Koichiro Yasuda⁶  Takeshi Kurose⁸  Nobuya Inagaki⁷  Yutaka Seino⁸ 

[1] Division of Diabetes and Endocrinology, Kyoto Preventive Medical Center, Kyoto, Japan;Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan;Department of Systems Engineering, Faculty of Computer Science and Systems Engineering, Okayama Prefectural University, Okayama, Japan;Division of Clinical Nutrition and Internal Medicine, Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan;Kyoto Institute of Health Science, Kyoto, Japan;Department of Diabetes and Endocrinology, Saiseikai Noe Hospital, Osaka, Japan;Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan;Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, Osaka, Japan;Center for Preventive Medicine, St. Luke's International Hospital, Tokyo, Japan

关键词: Fasting plasma glucose;    Post‐challenge plasma glucose;    Type 2 diabetes;   

DOI  :  10.1111/jdi.12239

来源: Wiley

【 摘 要 】

Abstract

Aims/Introduction

Elevation of 2-h plasma glucose (2-h PG) levels keeps step with fasting plasma glucose (FPG) levels elevation, but some individuals show dominant elevation of 2-h PG and others FPG. We analyzed dependent and independent relationships between 2-h PG and FPG, and investigated the factors regulating 2-h PG and FPG.

Materials and Methods

In 1,657 Japanese participants who underwent a 75-g oral glucose tolerance test at the initial examination for a medical check-up, we carried out simple linear regression analysis between 2-h PG and FPG levels on the three patterns of independent variables. We divided the participants into two subgroups: the 2-h PG-side group and the FPG-side from the regression line, and examined the relationships between 2-h PG-FPG and factors responsible for elevation of plasma glucose levels.

Results

There was a significant positive correlation between 2-h PG and FPG levels. The regression line of both 2-h PG and FPG as independent variables was in accordance with the regression line of 2-h PG as an independent variable and FPG as a dependent variable. In 2-h PG-side group, age was the independent factor affecting 2-h PG in addition to insulinogenic index and insulin sensitivity index (ISI composite). In the FPG-side group, triglyceride was the independent factor affecting FPG in addition to insulinogenic index and ISI composite.

Conclusions

Two-hour PG was an independent predictor of FPG. In addition to the importance of decreased insulin secretion and insulin sensitivity, age was the strong factor to elevate 2-h PG levels in the 2-h PG-side group and triglyceride was the strong factor to elevate FPG levels in the FPG-side group in the early stage of development of type 2 diabetes.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.