Hemoglobin A1c values are affected by hemoglobin level and gender in non‐anemic Koreans

Journal of Diabetes Investigation

Ji Cheol Bae³  Sunghwan Suh¹  Sang-Man Jin³  Se Won Kim³  Kyu Yeon Hur³  Jae Hyeon Kim³  Yong-Ki Min³  Myung-Shik Lee³  Moon Kyu Lee³  Won Seon Jeon²  Won Young Lee² 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Dong-A University Medical Center, Busan, Korea;Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea;Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Seoul, Korea

关键词: Gender;    Hemoglobin;    Hemoglobin A1c;   

DOI  :  10.1111/jdi.12123

来源: Wiley

【 摘 要 】

Abstract

Aims/Introduction

To evaluate whether hemoglobin A1c (HbA1c) levels are affected by hemoglobin level and gender.

Materials and Methods

A cross-sectional analysis was carried out in a sample of 87,284 non-diabetic Koreans without anemia who participated in comprehensive health check-ups between January and December 2009 at the Kangbuk Samsung Hospital Total Healthcare Center in Seoul, Korea. We categorized men and women separately according to fasting plasma glucose and hemoglobin level to carry out the analysis.

Results

HbA1c increased steadily with increasing fasting plasma glucose level. Both men and women with lower hemoglobin had significantly higher HbA1c at a given fasting glucose level, and this result was consistent across the fasting glucose quintiles within the non-diabetic range. Women had a lower mean hemoglobin value compared with men, and women had higher HbA1c levels at a given fasting glucose level consistently across the fasting glucose deciles. There was also a gender-specific association between age and HbA1c (P < 0.001 for interaction).

Conclusions

HbA1c values were affected by hemoglobin level and gender in non-anemic Koreans. Thus, hemoglobin level and gender should be considered in the diagnosis of diabetes using HbA1c.

【 授权许可】

CC BY-NC-ND   
© 2013 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.