Biomarkers for physical frailty and sarcopenia: state of the science and future developments

Journal of Cachexia, Sarcopenia and Muscle

Riccardo Calvani⁴  Federico Marini⁵  Matteo Cesari¹  Matteo Tosato⁴  Stefan D. Anker²  Stephan von Haehling²  Ram R. Miller³  Roberto Bernabei⁴  Francesco Landi⁴  Emanuele Marzetti⁴ 

[1] Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France;Department of Innovative Clinical Trials, University Medical Center Göttingen (UMG), Göttingen, Germany;Muscle Metabolism Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline R&D, Research Triangle Park, NC, USA;Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy;Department of Chemistry, “Sapienza” University of Rome, Rome, Italy

关键词: Ageing;    Disability;    Physical performance;    Circulating markers;    Imaging;    Multivariate modelling;   

DOI  :  10.1002/jcsm.12051

来源: Wiley

【 摘 要 】

Abstract

Physical frailty and sarcopenia are two common and largely overlapping geriatric conditions upstream of the disabling cascade. The lack of a unique operational definition for physical frailty and sarcopenia and the complex underlying pathophysiology make the development of biomarkers for these conditions extremely challenging. Indeed, the current definitional ambiguities of physical frailty and sarcopenia, together with their heterogeneous clinical manifestations, impact the accuracy, specificity, and sensitivity of individual biomarkers proposed so far. In this review, the current state of the art in the development of biomarkers for physical frailty and sarcopenia is presented. A novel approach for biomarker identification and validation is also introduced that moves from the ‘one fits all’ paradigm to a multivariate methodology.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society of Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.