Antibody‐ and aptamer‐strategies for GvHD prevention

Journal of Cellular and Molecular Medicine

Christopher Oelkrug⁴  Ulrich Sack¹  Andreas Boldt²  Isis C. Nascimento³  Henning Ulrich³ 

[1] Institute of Clinical Immunology, Universität Leipzig, Leipzig, Germany;Translational Centre for Regenerative Medicine, Universität Leipzig, Leipzig, Germany;Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil;Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany

关键词: antibody;    aptamer;    GvHD;    GvL;    murine model;    transplantation;   

DOI  :  10.1111/jcmm.12416

来源: Wiley

【 摘 要 】

Abstract

Prevention of Graft-versus-Host-Disease (GvHD) by preserved Graft-versus-Leukaemia (GvL) effect is one of the major obstacles following allogeneic haematopoietic stem cell transplantation. Currently used drugs are associated with side effects and were not able to separate GvHD from the GvL-effect because of general T-cell suppression. This review focuses on murine models for GvHD and currently available treatment options involving antibodies and applications for the therapeutic use of aptamers as well as strategies for targeting immune responses by allogenic antigens.

【 授权许可】

CC BY   
© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.