Association of chemerin with oxidative stress, inflammation and classical adipokines in non‐diabetic obese patients

Journal of Cellular and Molecular Medicine

Péter Fülöp¹  Ildikó Seres¹  Hajnalka Lőrincz¹  Mariann Harangi¹  Sándor Somodi¹ 

[1]Division of Metabolic Diseases, Department of Internal Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

关键词: obesity;    chemerin;    leptin;    adiponectin;    oxidized low‐density lipoprotein;    paraoxonase‐1;    inflammation;   

DOI  :  10.1111/jcmm.12282

来源: Wiley

【 摘 要 】

Abstract

The prevalence of obesity has been increasing worldwide. Chemerin is a recently discovered adipokine secreted by the enlarged adipose tissue with diverse biological effects that are not well detailed yet. This study aimed to elucidate the potential role of chemerin in oxidative stress and inflammation that are characteristics for excess weight and may eventually lead to insulin resistance and atherosclerotic complications. We also analysed the associations between chemerin and classical adipokines, namely leptin and adiponectin. Therefore, we investigated non-diabetic obese patients without manifest cardiovascular disease and compared their data to healthy lean individuals. Chemerin correlated positively with markers of oxidative stress and inflammation, while it showed a negative correlation with the measure of antioxidant status, characterized by the HDL-linked paraoxonase-1 enzyme. Chemerin also correlated positively with leptin and negatively with adiponectin respectively. In our study population, oxidized low-density lipoprotein and high-sensitivity C-reactive protein were found to be the strongest predictors of chemerin level. We conclude that chemerin may contribute to chronic inflammation and increased oxidative stress in obese individuals, even in the absence of manifest insulin resistance.

【 授权许可】

CC BY   
© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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