Telocytes in liver: electron microscopic and immunofluorescent evidence

Journal of Cellular and Molecular Medicine

Junjie Xiao²  Fei Wang¹  Zhenguo Liu² 

[1] Division of Gastroenterology and Hepatology, Digestive Disease Institute, Tongji Hospital, Tongji University School of Medicine, Shanghai, China;Regeneration Lab and Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai, China

关键词: telocytes;    telopodes;    liver;    CD34;    c‐kit;    vimentin;    PDGFR‐α;    β;    hepatic putative stem cells;   

DOI  :  10.1111/jcmm.12195

来源: Wiley

【 摘 要 】

Abstract

Hepatic interstitial cells play a vital role in regulating essential biological processes of the liver. Telocytes (TCs), a novel type of interstitial cells firstly identified by Popescu and his coworkers, have been reported in many tissues and organs, but not yet in liver (go to http://www.telocytes.com). We used transmission electron microscopy and immunofluorescence (double labelling for CD34 and c-kit/CD117, or vimentin, or PDGF Receptor-α, or β) to provide evidence for the existence of TCs in mice liver. The distribution of TCs in liver was found to be of similar density in the four hepatic lobes. In conclusion, here we show the presence of TCs in mice liver. It remains to be determined the possible roles of TCs in the control of liver homeostasis and regeneration, the more so as a close special relationship was found between TCs and hepatic putative stem (progenitor) cells.

【 授权许可】

CC BY   
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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