Cancer‐related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes

Journal of Cellular and Molecular Medicine

Petr Dmitriev²  Ulykbek Kairov³  Thomas Robert²  Ana Barat²  Vladimir Lazar²  Gilles Carnac¹  Dalila Laoudj-Chenivesse¹ 

[1] INSERM U1046, Université Montpellier I, Montpellier, France;UMR8126, Université Paris-Sud 11, CNRS, Institut de cancérologie Gustave Roussy, Villejuif, France;Department of Genomic and Personalized Medicine, Center for Life Sciences, Nazarbayev University, Astana, Kazakhstan

关键词: cancer;    rhabdomyosarcoma;    Ewing's sarcoma;    FSHD;    muscular dystrophy;   

DOI  :  10.1111/jcmm.12182

来源: Wiley

【 摘 要 】

Abstract

Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.

【 授权许可】

CC BY   
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.