Gene polymorphisms and chronic obstructive pulmonary disease

Journal of Cellular and Molecular Medicine

Xiaodan Wu²  Bowei Yuan¹  Elena López³  Chunxue Bai² 

[1] Harbin Medical University, Harbin, China;Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;Department of Oncohematology of Children, Hospital Universitario Niño Jesús, Madrid, Spain

关键词: chronic lung diseases;    COPD;    gene;    biomarkers;    polymorphism;    therapy;   

DOI  :  10.1111/jcmm.12159

来源: Wiley

【 摘 要 】

Abstract

The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease (COPD), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, severity, lung function, phenotypes, or drug effects, even though limited results from related studies lacked consistency. Most of these studies were association studies, rather than confirmatory studies. More large-sized and strictly controlled studies are needed to prove the relationship between gene polymorphisms and the reviewed traits. More importantly, prospective confirmatory studies beyond initial association studies will be necessary to evaluate true relationships between gene polymorphisms and COPD and help individualized treatment for patients with COPD.

【 授权许可】

CC BY   
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.