Mechanotransduction at focal adhesions: from physiology to cancer development

Journal of Cellular and Molecular Medicine

Jihye Seong¹  Ning Wang² 

[1] Neuroscience Program, University of Illinois, Urbana, IL, USA;Department of Mechanical Science and Engineering, University of Illinois, Urbana, IL, USA

关键词: Mechanotransduction;    Focal Adhesions;    Extracellular Matrix;    Integrin;    Cancer;    Invadopodia;   

DOI  :  10.1111/jcmm.12045

来源: Wiley

【 摘 要 】

Abstract

Living cells are continuously exposed to mechanical cues, and can translate these signals into biochemical information (e.g. mechanotransduction). This process is crucial in many normal cellular functions, e.g. cell adhesion, migration, proliferation, and survival, as well as the progression of diseases such as cancer. Focal adhesions are the major sites of interactions between extracellular mechanical environments and intracellular biochemical signalling molecules/cytoskeleton, and hence focal adhesion proteins have been suggested to play important roles in mechanotransduction. Here, we overview the current molecular understanding in mechanotransduction occurring at focal adhesions. We also introduce recent studies on how extracellular matrix and mechanical microenvironments contribute to the development of cancer.

【 授权许可】

CC BY   
© 2013 The Authors Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.