Viral and bacterial aetiology of community‐acquired pneumonia in adults

Influenza and Other Respiratory Viruses

Elisabeth G. W. Huijskens¹  Adriana J. M. van Erkel¹  Fernand M. H. Palmen¹  Anton G. M. Buiting¹  Jan A. J. W. Kluytmans¹ 

[1] Laboratory of Medical Microbiology and Immunology, St Elisabeth Hospital, Tilburg, The Netherlands.

关键词: Adults;    aetiology;    community‐acquired pneumonia;    respiratory virus infection;    viral;   

DOI  :  10.1111/j.1750-2659.2012.00425.x

来源: Wiley

【 摘 要 】

Abstract

Please cite this paper as: Huijskens et al. (2012) Viral and bacterial aetiology of community-acquired pneumonia in adults. Influenza and Other Respiratory Viruses 7(4), 567–573.

Background  Modern molecular techniques reveal new information on the role of respiratory viruses in community-acquired pneumonia. In this study, we tried to determine the prevalence of respiratory viruses and bacteria in patients with community-acquired pneumonia who were admitted to the hospital.

Methods  Between April 2008 and April 2009, 408 adult patients (aged between 20 and 94 years) with community-acquired pneumonia were tested for the presence of respiratory pathogens using bacterial cultures, real-time PCR for viruses and bacteria, urinary antigen testing for Legionella and Pneumococci and serology for the presence of viral and bacterial pathogens.

Results  Pathogens were identified in 263 (64·5%) of the 408 patients. The most common single organisms in these 263 patients were Streptococcus pneumoniae (22·8%), Coxiella burnetii (6·8%) and influenza A virus (3·8%). Of the 263 patients detected with pathogens, 117 (44·5%) patients were positive for one or more viral pathogens. Of these 117 patients, 52 (44·4%) had no bacterial pathogen. Multiple virus infections (≥2) were found in 16 patients.

Conclusion  In conclusion, respiratory viruses are frequently found in patients with CAP and may therefore play an important role in the aetiology of this disease.

【 授权许可】

Unknown   
© 2012 John Wiley & Sons Ltd