Serologic evidence of human influenza virus infections in swine populations, Cambodia

Influenza and Other Respiratory Viruses

Sareth Rith⁵  Punnaporn Netrabukkana⁴  San Sorn³  Elizabeth Mumford¹  Channa Mey⁵  Davun Holl⁴  Flavie Goutard⁵  Bunthin Y⁵  Stan Fenwick⁴  Ian Robertson⁴  François Roger² 

[1] World Health Organization, Global Influenza Programme, Geneva, Switzerland.;French Agricultural Research Center for International Development (CIRAD), Animal and Integrated Risk Management Research Unit (AGIRs), Montpellier, France.;National Veterinary Research Institute, Department of Animal Health Production, Ministry of Agriculture Forestry and Fisheries, Phnom Penh, Cambodia.;School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, Murdoch, WA, Australia.;Institut Pasteur in Cambodia, Virology Unit, Réseau International des Instituts Pasteur, Phnom Penh, Cambodia.

关键词: Cambodia;    influenza A viruses;    pig;    serology;   

DOI  :  10.1111/j.1750-2659.2012.00382.x

来源: Wiley

【 摘 要 】

Abstract

Background  This study was conducted from 2006 to 2010 and investigated the seroprevalence of influenza A viruses in Cambodian pigs, including human H1N1, H3N2, 2009 pandemic H1N1 (A(H1N1)pdm09), and highly pathogenic avian H5N1 influenza A viruses.

Methods  A total of 1147 sera obtained from pigs in Cambodia were tested by haemagglutination inhibition (HI) assays for antibody to human influenza A viruses along with both HI and microneutralization (MN) tests to assess immunological responses to H5N1 virus. The results were compared by year, age, and province.

Results  Antibodies against a human influenza A virus were detected in 14·9% of samples. A(H1N1)pdm09 virus were dominant over the study period (23·1%), followed by those to human H1N1 (17·3%) and H3N2 subtypes (9·9%). No pigs were serologically positive for avian H5 influenza viruses. The seroprevalence of human H1N1 and H3N2 influenza viruses peaked in 2008, while that of A(H1N1)pdm09 reached a peak in 2010. No significant differences in seroprevalence to human influenza subtypes were observed in different age groups.

Conclusions  Cambodian pigs were exposed to human strains of influenza A viruses either prior to or during this study. The implications of these high prevalence rates imply human-to-swine influenza virus transmission in Cambodia. Although pigs are mostly raised in small non-commercial farms, our preliminary results provide evidence of sustained human influenza virus circulation in pig populations in Cambodia.

【 授权许可】

Unknown   
© 2012 Blackwell Publishing Ltd