Safety and tolerability of a 6‐week course of oseltamivir prophylaxis for seasonal influenza in children

Influenza and Other Respiratory Viruses

Keith Reisinger¹  Daniel Shu³  Lisa Cupelli⁴  Isaac Marcadis² 

[1] Primary Physicians Research, Pittsburgh, PA, USA.;Palm Beach Research Centre, Palm Beach FL, USA.;Gain Medical Centre, Coquitlam, BC, Canada.;Hoffmann-La Roche Inc., Nutley, NJ, USA.

关键词: Children;    influenza;    oseltamivir;    prevention;    prophylaxis;   

DOI  :  10.1111/j.1750-2659.2012.00367.x

来源: Wiley

【 摘 要 】

Abstract

Please cite this paper as: Reisinger et al. Safety and tolerability of a 6-week course of oseltamivir prophylaxis for seasonal influenza in children. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00367.x.

In an open-label study, 49 children aged 1–12 years received oseltamivir (30–75 mg once daily depending on bodyweight) for 6 weeks for influenza prophylaxis. Seventeen participants reported 22 adverse events (AEs); in three participants, AEs were considered probably drug related (nausea or vomiting). No serious AEs were reported. The tolerability profile was similar to pooled safety data from treatment studies (duration of 5 days) in children.

【 授权许可】

Unknown   
© 2012 Blackwell Publishing Ltd