The post‐infection outcomes of influenza and acute respiratory infection in patients above 50 years of age in Japan: an observational study

Influenza and Other Respiratory Viruses

Hideyuki Ikematsu³  Yuriko Takeuchi¹  Mats Rosenlund¹  Naoki Kawai²  Ryuji Shimamura²  Miki Hirata² 

[1] GlaxoSmithKline Biologicals, Wavre, Belgium.;Japan Physicians Association, Tokyo, Japan;Department of Clinical Trials, Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan

关键词: Acute respiratory infection;    human metapneumovirus;    influenza;    influenza‐like illness;    post‐infection outcomes;    respiratory syncytial virus;    test‐negative case–control;    vaccine effectiveness;   

DOI  :  10.1111/j.1750-2659.2011.00296.x

来源: Wiley

【 摘 要 】

Abstract

Please cite this paper as: Ikematsu et al. (2011) The post-infection outcomes of influenza and acute respiratory infection in patients above 50 years of age in Japan: an observational study. Influenza and Other Respiratory Viruses 6(3), 211–217.

Objectives  Influenza can be a serious illness, especially for older people, and reducing the impact of influenza in elderly is important. The objective of this study was to estimate the prevalence and postinfection outcomes of influenza among the over-50 population in Japan.

Design  An observational study was designed to ascertain the proportion of influenza cases in a population aged ≥50 years with acute respiratory infection (ARI) and to determine the postinfection outcomes of their illness during the 2008–09 influenza season in Japan. Respiratory specimens obtained from a total of 401 patients were tested by PCR for influenza viruses, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). The effectiveness of the seasonal trivalent influenza vaccine was estimated by a test-negative case control analysis.

Setting  Seventeen outpatient clinics located in four separate areas of Japan.

Sample  Respiratory swab specimens from the ARI patients aged ≥50 years.

Main outcome measures  Laboratory confirmed influenza in patients presenting with ARI.

Results  In all, 89 (22.2%) of the patients were positive for one of the tested viruses; 70 (78.7%) with influenza, 17 (19.1%) with RSV, and 2 (2.2%) with hMPV. Cough (95.7% vs 73.4%), loss of appetite (67.1% vs 35.5%), absence from work (50.0% vs 23.0%), impact on daily activity (90.0% vs 62.5%), and caregiver absence from work (5.7% vs 0.6%) were observed higher in influenza patients. The duration of feeling weakness (6.3 ± 5.4 vs 3.6 ± 1.9 days) and average days of reduced activity (5.2 vs 3.6 days) were longer for influenza patients. Vaccine effectiveness was estimated to be 32.1% (95% CI: −14.9, 59.9%).

Conclusions  Influenza was the dominant ARI-causing virus and the clinical and socio-economic outcomes imposed on patients over 50 years of age was high for influenza.

【 授权许可】

Unknown   
© 2011 Blackwell Publishing Ltd