BDNF‐mediated migration of cardiac microvascular endothelial cells is impaired during ageing

Journal of Cellular and Molecular Medicine

Liang Cao¹  Liang Zhang¹  Siyun Chen¹  Ziqiang Yuan²  Shaokun Liu¹  Xiaotao Shen¹  Xin Zheng¹  Xufeng Qi¹  Kenneth K.H. Lee¹  John Yeuk-Hon Chan¹ 

[1] Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China;Department of Molecular Genetics, Albert Einstein College of Medicine, New York, NY, USA

关键词: ageing;    BDNF;    cardiac microvascular endothelial cells;    migration;    TrkB;   

DOI  :  10.1111/j.1582-4934.2012.01621.x

来源: Wiley

【 摘 要 】

Abstract

This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd