Human cardiomyocyte progenitor cells: a short history of nearly everything

Journal of Cellular and Molecular Medicine

Patrick van Vliet²  Marie-José Goumans¹  Pieter A. Doevendans² 

[1] Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands;Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands

关键词: cardiac stem cells;    regeneration;    microRNA;    miRNA;    cell therapy;    apoptosis;    necrosis;   

DOI  :  10.1111/j.1582-4934.2012.01535.x

来源: Wiley

【 摘 要 】

Abstract

The high occurrence of cardiac disease in the Western world has driven clinicians and cardiovascular biologists to look for alternative strategies to treat patients. A challenging approach is the use of stem cells to repair the heart, in itself an inspiring thought. In the past 10 years, stem cells from different sources have been under intense investigation and, as a result, a multitude of studies have been published on the identification, isolation, and characterization, of cardiovascular progenitor cells and repair in different animal models. However, relatively few cardiovascular progenitor populations have been identified in human hearts, including, but not limited to, cardiosphere-derived cells [1], cKit+ human cardiac stem cells [2], Isl1+ cardiovascular progenitors [3], and, in our lab, cardiomyocyte progenitor cells (CMPCs) [4, 5]. Here, we aim to provide a comprehensive summary of the past findings and present challenges for future therapeutic potential of CMPCs.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd