Large animal induced pluripotent stem cells as pre‐clinical models for studying human disease

Journal of Cellular and Molecular Medicine

Jordan R. Plews²  Mingxia Gu²  Michael T. Longaker¹ 

[1] Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA;Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA, USA

关键词: induced pluripotent stem cells;    large animal iPS;    disease modelling;    bovine;    canine;    porcine;    primate;   

DOI  :  10.1111/j.1582-4934.2012.01521.x

来源: Wiley

【 摘 要 】

Abstract

• The path to induced pluripotency
• Discovery of a pan-species pluripotency network
• Animal iPSCs and disease modelling
• Issues with large animal iPSCs
• Conclusions

The derivation of human embryonic stem cells and subsequently human induced pluripotent stem cells (iPSCs) has energized regenerative medicine research and enabled seemingly limitless applications. Although small animal models, such as mouse models, have played an important role in the progression of the field, typically, they are poor representations of the human disease phenotype. As an alternative, large animal models should be explored as a potentially better approach for clinical translation of cellular therapies. However, only fragmented information regarding the derivation, characterization and clinical usefulness of pluripotent large animal cells is currently available. Here, we briefly review the latest advances regarding the derivation and use of large animal iPSCs.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd