Alterations in the contractile phenotype of the bladder: lessons for understanding physiological and pathological remodelling of smooth muscle

Journal of Cellular and Molecular Medicine

Stephen A. Zderic¹ 

[1] The John W. Duckett Jr. Center for Pediatric Urology at The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

关键词: bladder;    outlet obstruction;    myosin;    smooth muscle;    hypertrophy;    remodelling;   

DOI  :  10.1111/j.1582-4934.2011.01368.x

来源: Wiley

【 摘 要 】

Abstract

• • Introduction
• • Alterations in bladder contractility with normal development
• • Assessment of bladder function in genetically modified mice
• • A whole organ perspective on the bladder’s response to pBOO
  • - Clinical observations
• • Experimental observations
• • In vivo measures of pBOO in a rabbit model
• • Relating muscle strip studies to whole organ function
• • Myosin light chain phosphorylation
• • Regulation of myosin light chain de-phosphorylation
• • Alterations in the thick contractile filaments
  • - SM1 and SM2 isoforms
  • - SM-B and SM-A isoforms
• • Regulatory light chain
• • Alterations in the thin contractile filaments
• • Alterations in tension transfer complex

The contractile properties of the urinary bladder are changed by the conditions of normal development and partial bladder outlet obstruction. This change in the contractile phenotype is accompanied by changes in the regulatory cascades and filaments that regulate contractility. This review focuses on such changes during the course of normal development and in response to obstruction. Our goal is to discuss the experimental evidence that has accumulated from work in animal models and correlate these findings with the human voiding phenotype.

【 授权许可】

Unknown   
© 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd