A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China

Influenza and Other Respiratory Viruses

Shengtao Fan⁴  Lichen Zhou¹  Di Wu²  Xiaolong Gao³  Enle Pei²  Tianhou Wang¹  Yuwei Gao⁵ 

[1] Laboratory of Wildlife Epidemic Diseases, East China Normal University, Shanghai, China;Shanghai Municipal Agency of Wildlife Conservation, Shanghai, China;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China;Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China;Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, China

关键词: H5N8;    highly pathogenic avian influenza virus;    wild duck;   

DOI  :  10.1111/irv.12289

来源: Wiley

【 摘 要 】

Abstract

Migrating wild birds are considered natural reservoirs of influenza viruses and serve as a potential source of novel influenza strains in humans and livestock. During routine avian influenza surveillance conducted in eastern China, a novel H5N8 (SH-9) reassortant influenza virus was isolated from a mallard duck in China. blast analysis revealed that the HA, NA, PB1, PA, NP, and M segments of SH-9 were most closely related to the corresponding segments of A/duck/Jiangsu/k1203/2010 (H5N8). The SH-9 virus preferentially recognized avian-like influenza virus receptors and was highly pathogenic in mice. Our results suggest that wild birds could acquire the H5N8 virus from breeding ducks and spread the virus via migratory bird flyways.

【 授权许可】

CC BY   
© 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd

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