Excess mortality impact of two epidemics of pandemic influenza A(H1N1pdm09) virus in Hong Kong

Influenza and Other Respiratory Viruses

Peng Wu²  Edward Goldstein¹  Lai-Ming Ho²  Joseph T. Wu²  Thomas Tsang³  Gabriel M. Leung² 

[1] Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China;Centre for Health Protection, Department of Health, Government of the Hong Kong Special Administrative Region, Hong Kong Special Administrative Region, China

关键词: Excess mortality;    H1N1pdm09;    impact;    influenza;    pandemic;   

DOI  :  10.1111/irv.12196

来源: Wiley

【 摘 要 】

Abstract

Hong Kong experienced two large epidemics of pandemic influenza A(H1N1pdm09). We used regression methods to estimate the excess mortality associated with each epidemic. The first epidemic of H1N1pdm09 peaked in September 2009 and was associated with 2·13 [95% confidence interval (CI): −8·08, 11·82] excess all-cause deaths per 100 000 population. The second epidemic of H1N1pdm09 in early 2011 was associated with 4·72 [95% CI: −0·70, 10·50] excess deaths per 100 000 population. More than half of the estimated excess all-cause deaths were attributable to respiratory causes in each epidemic. The reasons for substantial impact in the second wave remain to be clarified.

【 授权许可】

CC BY   
© 2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

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