Comparison of the clinical effectiveness of zanamivir and laninamivir octanoate for children with influenza A(H3N2) and B in the 2011–2012 season

Influenza and Other Respiratory Viruses

Naoko Koseki¹  Miki Kaiho¹  Hideaki Kikuta²  Koji Oba³  Takehiro Togashi⁴  Tadashi Ariga¹ 

[1] Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan;Pediatric Clinic, Touei Hospital, Sapporo, Japan;Translational Research and Clinical Trial Center, Hokkaido University Hospital, Sapporo, Japan;Sapporo City University School of Nursing, Sapporo, Japan

关键词: Biphasic fever;    influenza;    laninamivir octanoate;    neuraminidase inhibitors;    zanamivir;   

DOI  :  10.1111/irv.12147

来源: Wiley

【 摘 要 】

Abstract

Objectives

To evaluate the clinical effectiveness of the two inhaled neuraminidase inhibitors (NAIs), zanamivir (ZN) and laninamivir octate (LO), for influenza A(H3N2) and B virus infections.

Design

A prospective, multicenter observational study was conducted from January to April in 2012.

Setting

Outpatients aged 5–18 years who had a temperature of 37.5°C or higher and were diagnosed as having influenza based on an immunochromatographic assay were enrolled.

Sample

A total of 338 patients treated with ZN and 314 patients treated with LO were compared.

Main outcome measures

The duration of fever after administration of the first dose of each NAI was evaluated as a primary endpoint. The secondary endpoint was episodes of biphasic fever.

Results

No statistically significant difference in the duration of fever was found between the ZN and LO groups (log-rank test, P = 0.117). A logistic regression model showed that episodes of biphasic fever increased by 1.19 times for every decrease of 1 year of age (P = 0.016) and that the number of biphasic fever episodes in patients treated with LO was 5.80-times greater than that in patients treated with ZN (P < 0.001).

Conclusions

Although the duration of fever in the LO group was comparable to that in the ZN group, episodes of biphasic fever were more frequent in younger children and in the LO group than in the ZN group.

【 授权许可】

CC BY   
© 2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.