期刊论文详细信息
Influenza and Other Respiratory Viruses
Progressive emergence of an oseltamivir‐resistant A(H3N2) virus over two courses of oseltamivir treatment in an immunocompromised paediatric patient
Aeron C. Hurt2  Sook Kwan Leang2  Karin Tiedemann1  Jeff Butler2  Francoise Mechinaud1  Anne Kelso2  Peter Downie1 
[1] Children's Cancer Centre, Royal Children's Hospital, Melbourne, Vic., Australia;WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Vic., Australia
关键词: E119V NA mutation;    immunocompromised;    influenza;    oseltamivir resistance;   
DOI  :  10.1111/irv.12108
来源: Wiley
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【 摘 要 】

Abstract

A minor viral population of oseltamivir-resistant A(H3N2) viruses (E119V neuraminidase mutation) was selected and maintained in a continually infected immunocompromised child following initial oseltamivir treatment. A subsequent course of oseltamivir given 7 weeks later rapidly selected for the E119V variant resulting in a near-pure population of the resistant virus. The study highlights the challenges of oseltamivir treatment of immunocompromised patients that are continually shedding virus and demonstrates the ability of the E119V oseltamivir-resistant virus to be maintained for prolonged periods even in the absence of drug-selective pressure.

【 授权许可】

Unknown   
© 2013 John Wiley & Sons Ltd

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