Incidence of influenza‐associated mortality and hospitalizations in Argentina during 2002–2009

Influenza and Other Respiratory Viruses

Eduardo Azziz-Baumgartner⁷  Ana María Cabrera⁴  Po-Yung Cheng⁷  Enio Garcia⁴  Gabriela Kusznierz²  Rogelio Calli⁶  Clarisa Baez⁵  María Pía Buyayisqui⁴  Eleonora Poyard⁴  Emanuel Pérez²  Ricardo Basurto-Davila⁷  Rakhee Palekar⁷  Otavio Oliva¹  Airlane Pereira Alencar³  Regilo de Souza¹  Thais dos Santos¹  David K. Shay⁷  Marc-Alain Widdowson⁷  Joseph Breese⁷ 

[1] Pan American Health Organization.;Instituto Nacional de Enfermedades Respiratorias ‘Dr. Emilio Coni,’ Argentina.;Institute of Mathematics and Statistics – University of São Paulo, Brazil.;Dirección de Epidemiología, Ministerio de Salud de la Nación, Argentina.;Ministerio de Salud de la Provincia de Buenos Aires, Buenos Aires, Argentina.;Dirección de Epidemiología, Ministerio de Salud Pública Provincia de Tucumán, Argentina.;Influenza Division, U.S. Centers for Disease Control and Prevention, USA.

关键词: Argentina;    hospitalizations;    incidence;    influenza;    mortality;    respiratory;   

DOI  :  10.1111/irv.12022

来源: Wiley

【 摘 要 】

Abstract

Please cite this paper as: Azziz-Baumgartner et al. (2012) Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002–2009. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12022.

Background  We estimated rates of influenza-associated deaths and hospitalizations in Argentina, a country that recommends annual influenza vaccination for persons at high risk of complications from influenza illness.

Methods  We identified hospitalized persons and deaths in persons diagnosed with pneumonia and influenza (P&I, ICD-10 codes J10-J18) and respiratory and circulatory illness (R&C, codes I00-I99 and J00-J99). We defined the influenza season as the months when the proportion of samples that tested positive for influenza exceeded the annual median. We used hospitalizations and deaths during the influenza off-season to estimate, using linear regression, the number of excess deaths that occurred during the influenza season. To explore whether excess mortality varied by sex and whether people were age <65 or ≥65 years, we used Poisson regression of the influenza-associated rates.

Results  During 2002–2009, 2411 P&I and 8527 R&C mean excess deaths occurred annually from May to October. If all of these excess deaths were associated with influenza, the influenza-associated mortality rate was 6/100 000 person-years (95% CI 4–8/100 000 person-years for P&I and 21/100 000 person-years (95% CI 12–31/100 000 person-years) for R&C. During 2005–2008, we identified an average of 7868 P&I excess hospitalizations and 22 994 R&C hospitalizations per year, resulting in an influenza-associated hospitalization rate of 2/10 000 person-years (95% CI 1–3/10 000 person-years) for P&I and 6/10 000 person-years (95% CI 3–8/10 000 person-years) for R&C.

Conclusion  Our findings suggest that annual rates of influenza-associated hospitalizations and death in Argentina were substantial and similar to neighboring Brazil.

【 授权许可】

Unknown   
Published 2012. This article is a US Government work and is in the public domain in the USA.