Functional profile of S100A4‐deficient T cells

Immunity, Inflammation and Disease

Kathleen Weatherly¹  Marie Bettonville¹  David Torres¹  Arnaud Kohler¹  Stanislas Goriely¹ 

[1] Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Gosselies, Belgium

关键词: Ca‐binding protein;    T cell;    motility;    inflammation;   

DOI  :  10.1002/iid3.85

来源: Wiley

【 摘 要 】

Abstract

The protein S100A4 is best known for its significant role in promoting motility and invasive capacity of cancer cells. Since S100A4 expression has been reported also in T cells, we analyzed its potential role in T cell motility and inflammation. Using S100a4^+/Gfp mice, we show here that S100A4 is exclusively expressed by memory T cells of CD4⁺ or CD8⁺ subpopulations, predominantly of the effector memory T cell subtype. However, the protein was not required for in vitro memory T cell migration toward gradients of the inflammatory chemokine CXCL10. Moreover, T cell memory response was normal in S100A4-deficient mice and lack of S100a4 gene expression did not induce any defect in promoting the development of protective immunity or inflammatory reactions leading to autoimmunity. Taken together, our results demonstrate that S100A4 activity is dispensable for T cell motility/migration and inflammatory potential.

【 授权许可】

CC BY   
© 2015 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.