Understanding the biosynthesis of platelets‐derived extracellular vesicles

Immunity, Inflammation and Disease

Samuel Antwi-Baffour¹  Jonathan Adjei¹  Claudia Aryeh¹  Ransford Kyeremeh¹  Foster Kyei² 

[1] Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, 143, Korle-Bu, Accra, Ghana;College of Agriculture and Natural Sciences, School of Biological Sciences, Department of Molecular Biology and Biotechnology, University of Cape Coast, Cape Coast, Ghana

关键词: Actin;    biomarkers;    centrifugation;    extracellular vesicles;    phosphatidylserine;    phospholipids;   

DOI  :  10.1002/iid3.66

来源: Wiley

【 摘 要 】

Abstract

Platelet-derived extracellular vesicles (PEVs) are described as sub-cellular vesicles released into circulation upon platelets shear stress, activation, injury, or apoptosis. They are considered as universal biomarkers in a wide range of physiological and pathological processes. They are of tremendous significance for the prediction, diagnosis, and observation of the therapeutic success of many diseases. Understanding their biosynthesis and therefore functional properties would contribute to a better understanding of the pathological mechanisms leading to various diseases in which their levels are raised and they are implicated. The review takes a critical look at the historical background of PEVs, their structural components, the mechanism of their formation, physiological, and exogenous stimuli inducing their release and their detection. It concludes by highlighting on the importance of undertaking in-depth studies into PEVs biosynthesis and subsequently gaining a better understanding of their biological role in general.

【 授权许可】

CC BY   
© 2015 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.