Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus

Evolutionary Applications

Vanessa Weber de Melo¹  Hanan Sheikh Ali⁴  Jona Freise⁵  Denise Kühnert²  Sandra Essbauer³  Marc Mertens⁴  Konrad M. Wanka⁴  Stephan Drewes⁴  Rainer G. Ulrich⁴ 

[1] Computational and Molecular Population Genetics (CMPG), Institute of Ecology and Evolution, University of Bern, Bern, Switzerland;Department of Environmental Systems Science, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland;Department of Virology & Rickettsiology, Bundeswehr Institute of Microbiology, Munich, Germany;Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany;Fachbereich Schädlingsbekämpfung, Niedersächsisches Landesamt für Verbraucherschutz und Lebensmittelsicherheit, Wardenburg, Germany

关键词: bank vole;    genetic structure;    hantavirus;    host–parasite evolution;    nephropathia epidemica;    population dynamics;    rodent‐borne disease;    zoonosis;   

DOI  :  10.1111/eva.12263

来源: Wiley

【 摘 要 】

Abstract

Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations, but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.

【 授权许可】

CC BY   
© 2015 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.

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