Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health

Evolutionary Applications

Gabriel G. Perron²  R. Fredrik Inglis¹  Pleuni S. Pennings³ 

[1] Department of Biology, Washington University in St. Louis, St. Louis, MO, USA;Department of Biology, Bard College, Annandale-on-Hudson, NY, USA;Department of Biology, San Francisco State University, San Francisco, CA, USA

关键词: adaptation;    antibiotic resistance;    ecology;    epidemiology;    experimental evolution;    genomics;    HIV;    malaria;    population genetics;   

DOI  :  10.1111/eva.12254

来源: Wiley

【 摘 要 】

Abstract

Although microbes have been evolving resistance to antimicrobials for millennia, the spread of resistance in pathogen populations calls for the development of new drugs and treatment strategies. We propose that successful, long-term resistance management requires a better understanding of how resistance evolves in the first place. This is an opportunity for evolutionary biologists to engage in public health, a collaboration that has substantial precedent. Resistance evolution has been an important tool for developing and testing evolutionary theory, especially theory related to the genetic basis of new traits and constraints on adaptation. The present era is no exception. The articles in this issue highlight the breadth of current research on resistance evolution and also its challenges. In this introduction, we review the conceptual advances that have been achieved from studying resistance evolution and describe a path forward.

【 授权许可】

CC BY   
© 2015 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.