An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control

Evolutionary Applications

Clare D. Marsden²  Anthony Cornel⁴  Yoosook Lee²  Michelle R. Sanford²  Laura C. Norris²  Parker B. Goodell²  Catelyn C. Nieman²  Sarah Han²  Amabelia Rodrigues³  Joao Denis³  Ahmed Ouledi¹ 

[1] Université des Comores, rue de la Corniche, Moroni, Grande Comore, Union of Comoros;Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA;National Institute of Public Health (INASA), Bissau, Guinea-Bissau;Department of Entomology, University of California, Davis, CA, USA

关键词: Anopheles gambiae;    Bijagós;    Comoros;    genetically modified mosquitoes;    island population;    isolation;   

DOI  :  10.1111/eva.12056

来源: Wiley

【 摘 要 】

Abstract

Considerable technological advances have been made towards the generation of genetically modified mosquitoes for vector control. In contrast, less progress has been made towards field evaluations of transformed mosquitoes which are critical for evaluating the success of, and hazards associated with, genetic modification. Oceanic islands have been highlighted as potentially the best locations for such trials. However, population genetic studies are necessary to verify isolation. Here, we used a panel of genetic markers to assess for evidence of genetic isolation of two oceanic island populations of the African malaria vector, Anopheles gambiae s.s. We found no evidence of isolation between the Bijagós archipelago and mainland Guinea-Bissau, despite separation by distances beyond the known dispersal capabilities of this taxon. Conversely, the Comoros Islands appear to be genetically isolated from the East African mainland, and thus represent a location worthy of further investigation for field trials. Based on assessments of gene flow within and between the Comoros islands, the island of Grande Comore was found to be genetically isolated from adjacent islands and also exhibited local population structure, indicating that it may be the most suitable site for trials with existing genetic modification technologies.

【 授权许可】

CC BY   
© 2013 The Authors. Evolutionary Applications published by Blackwell Publishing Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.