Applying ecological and evolutionary theory to cancer: a long and winding road

Evolutionary Applications

Frédéric Thomas⁵  Daniel Fisher⁵  Philippe Fort⁵  Jean-Pierre Marie⁶  Simon Daoust⁴  Benjamin Roche⁵  Christoph Grunau⁸  Céline Cosseau⁸  Guillaume Mitta⁸  Stephen Baghdiguian⁹  François Rousset⁹  Patrice Lassus⁵  Eric Assenat¹¹  Damien Grégoire¹¹  Dorothée Missé⁴  Alexander Lorz¹  Frédérique Billy¹  William Vainchenker²  François Delhommeau³  Serge Koscielny²  Raphael Itzykson²  Ruoping Tang⁶  Fanny Fava⁶  Annabelle Ballesta¹  Thomas Lepoutre^5,10  Liliana Krasinska¹¹  Vjekoslav Dulic¹¹  Peggy Raynaud^5,7  Philippe Blache^5,7  Corinne Quittau-Prevostel^5,7  Emmanuel Vignal^5,7  Hélène Trauchessec^5,7  Benoit Perthame¹  Jean Clairambault¹  Vitali Volpert^5,10  Eric Solary²  Urszula Hibner⁵ 

[1] INRIA Paris-Rocquencourt, CNRS UMR 7598 and UPMC Laboratoire Jacques-Louis Lions, Paris cedex 05, France;INSERM UMR 1009, Institut Gustave Roussy, Villejuif, France;UPMC Univ Paris 06, Paris, France;MIVEGEC (UMR CNRS/IRD/UM1) 5290, Montpellier Cedex 5, France;CREEC, Montpellier Cedex 5, France;UPMC, UMRs872 and Saint-Antoine Hospital, AP-HP Paris, France;Université Montpellier 1, Montpellier, France;UPVD, Perpignan, France;Université Montpellier 2, Montpellier, France;CNRS – INRIA UMR 5208 Institut Camille Jordan, Université Lyon 1, Lyon, France;IGMM, CNRS UMR 5535, Montpellier, France

关键词: cancer;    disease biology;    evolutionary medicine;    evolutionary theory;   

DOI  :  10.1111/eva.12021

来源: Wiley

【 摘 要 】

Abstract

Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.

【 授权许可】

CC BY   
© 2012 The Authors. Evolutionary Applications published by Blackwell Publishing Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.