Association mapping of genetic risk factors for chronic wasting disease in wild deer

Evolutionary Applications

Tomomi Matsumoto⁴  Michael D. Samuel³  Trent Bollinger²  Margo Pybus¹ 

[1] Division of Fish and Wildlife, Alberta Sustainable Resource Development, Edmonton, AB, Canada;Department of Veterinary Pathology, Canadian Cooperative Wildlife Health Centre, University of Saskatchewan, Saskatoon, SK, Canada;US Geological Survey, Wisconsin Cooperative Wildlife Research Unit, University of Wisconsin, Madison, WI, USA;Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada

关键词: chronic wasting disease;    genetic risk factor;    linkage disequilibrium;    microsatellite markers;    mule deer;    NF1;    PRNP;    white‐tailed deer;   

DOI  :  10.1111/eva.12003

来源: Wiley

【 摘 要 】

Abstract

Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross-species amplification rate (27.9%) and showed weak linkage disequilibrium (<1 cM). Markers near the prion protein and the neurofibromin 1 (NF1) genes were suggestively associated with CWD status in white-tailed deer (P = 0.006) and mule deer (P = 0.02), respectively. This is the first time an association between the NF1 region and CWD has been reported.

【 授权许可】

CC BY-NC   
© 2012 The Authors. Evolutionary Applications published by Blackwell Publishing Ltd.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.