A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL‐10 dependent derivatives of inflammatory monocytes

EMBO Molecular Medicine

Cindy Fevre⁴  Ana S. Almeida¹  Solenne Taront¹  Thierry Pedron¹  Michel Huerre⁵  Marie-Christine Prevost²  Aurélie Kieusseian³  Ana Cumano³  Sylvain Brisse⁴  Philippe J. Sansonetti¹ 

[1] Institut Pasteur, Pathogénie Microbienne Moléculaire, Paris Cedex, France;Institut Pasteur, Plateforme de Microscopie Ultrastructurale, Paris Cedex, France;Institut Pasteur, Unité du Développement des Lymphocytes, Paris Cedex, France;Institut Pasteur, Génotypage des Pathogènes et Santé Publique, Paris Cedex, France;Institut Pasteur, Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Paris Cedex, France

关键词: IL‐10;    inflammatory monocytes;    Klebsiella;    Mikulicz cell;    rhinoscleroma;   

DOI  :  10.1002/emmm.201202023

来源: Wiley

【 摘 要 】

Abstract

Rhinoscleroma is a human specific chronic disease characterized by the formation of granuloma in the airways, caused by the bacterium Klebsiella pneumoniae subspecies rhinoscleromatis, a species very closely related to K. pneumoniae subspecies pneumoniae. It is characterized by the appearance of specific foamy macrophages called Mikulicz cells. However, very little is known about the pathophysiological processes underlying rhinoscleroma. Herein, we characterized a murine model recapitulating the formation of Mikulicz cells in lungs and identified them as atypical inflammatory monocytes specifically recruited from the bone marrow upon K. rhinoscleromatis infection in a CCR2-independent manner. While K. pneumoniae and K. rhinoscleromatis infections induced a classical inflammatory reaction, K. rhinoscleromatis infection was characterized by a strong production of IL-10 concomitant to the appearance of Mikulicz cells. Strikingly, in the absence of IL-10, very few Mikulicz cells were observed, confirming a crucial role of IL-10 in the establishment of a proper environment leading to the maturation of these atypical monocytes. This is the first characterization of the environment leading to Mikulicz cells maturation and their identification as inflammatory monocytes.

【 授权许可】

CC BY   
Copyright © 2013 EMBO Molecular Medicine

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