Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications

EMBO Molecular Medicine

Simone Fulda¹  Krishnaraj Rajalingam² 

[1] Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany;Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt am Main, Germany

关键词: apoptosis;    cell death;    inflammation;    NF‐κB;    ubiquitin;   

DOI  :  10.1002/emmm.201100707

来源: Wiley

【 摘 要 】

Abstract

Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes. What was once regarded as a mere signal for protein degradation has turned out to be a major regulator of molecular signalling networks. Deregulation of ubiquitin signalling is closely associated with various human pathologies. Here, we summarize the current knowledge of ubiquitin signalling in immune deficiencies and cancer as well as the available therapeutic strategies targeting the ubiquitin system in combating these pathogenic conditions.

【 授权许可】

CC BY   
Copyright © 2012 EMBO Molecular Medicine

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.