Balancing the fat: lipid droplets and human disease

EMBO Molecular Medicine

Natalie Krahmer²  Robert V. Farese Jr¹ 

[1] Gladstone Institutes, Departments of Medicine and Biochemistry & Biophysics, University of California, San Francisco, CA, USA;Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA

关键词: atherosclerosis;    lipid droplet;    lipodystrophy;    metabolic syndrome;    triglyceride storage;   

DOI  :  10.1002/emmm.201100671

来源: Wiley

【 摘 要 】

Abstract

Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.

【 授权许可】

CC BY   
Copyright © 2013 EMBO Molecular Medicine

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.