Vitamin D status in cats with feline immunodeficiency virus

Veterinary Medicine and Science

Helen F. Titmarsh¹  Stephanie M. Lalor¹  Severine Tasker²  Emily N. Barker²  Jacqueline Berry³  Danielle Gunn-More¹ 

[1] The Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Roslin, Edinburgh, UK;School of Veterinary Sciences, University of Bristol, Langford, Bristol, UK;Vitamin D Research Laboratory, Department of Medicine, Manchester Royal Infirmary, Manchester, UK

关键词: vitamin D;    feline;    feline immunodeficiency virus;    25(OH)D;    human immunodeficiency virus;   

DOI  :  10.1002/vms3.11

来源: Wiley

【 摘 要 】

Abstract

Feline immunodeficiency virus (FIV) is a lentivirus that can lead to a syndrome of acquired immune dysfunction. Infected cats often remain asymptomatic for several years before immune dysfunction leads to an increased risk for the development of systemic diseases, neoplasia and opportunistic infections. FIV is structurally related to human immunodeficiency virus (HIV) and the pathogenesis of FIV-related disease is similar to that seen in HIV-infected patients. Observational studies have documented an association between low plasma vitamin D and HIV infection. Vitamin D status has been shown to be associated with HIV-related disease progression, morbidity and mortality. The objective of this study was to examine the hypothesis that vitamin D status, as assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations, are lower in cats with FIV infection compared to healthy control cats. Serum 25(OH)D concentrations were measured in 20 healthy cats, 39 hospitalized ill cats and 59 cats infected with FIV. Cats which were FIV infected had significantly lower 25(OH)D concentrations compared to healthy control cats. Serum 25(OH)D concentrations were not significantly different between FIV-infected cats and hospitalized ill cats. Further investigations are warranted to determine whether vitamin D status influences the prognosis of cats infected with FIV.

【 授权许可】

CC BY   
© 2015 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd.

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