The mammalian blastema: regeneration at our fingertips

Regeneration

Jennifer Simkin¹  Mimi C. Sammarco¹  Lindsay A. Dawson¹  Paula P. Schanes¹  Ling Yu¹ 

[1] Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, USA

关键词: Blastema;    digit;    hypoxia;    mouse;    regeneration;    stem cells;    wound healing;   

DOI  :  10.1002/reg2.36

来源: Wiley

【 摘 要 】

Abstract

In the mouse, digit tip regeneration progresses through a series of discrete stages that include inflammation, histolysis, epidermal closure, blastema formation, and redifferentiation. Recent studies reveal how each regenerative stage influences subsequent stages to establish a blastema that directs the successful regeneration of a complex mammalian structure. The focus of this review is on early events of healing and how an amputation wound transitions into a functional blastema. The stepwise formation of a mammalian blastema is proposed to provide a model for how specific targeted treatments can enhance regenerative performance in humans.

【 授权许可】

CC BY   
© 2015 The Authors. Regeneration published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.