Henoch–Schonlein purpura in mesothelioma

Respirology Case Reports

Stuti Joshi²  Sooraj Pillai¹  Aron Chakera³ 

[1] PathWest Laboratory Medicine, QE II Med Ctr, Perth, Western Australia, Australia;Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia;Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia

关键词: Henoch–Schonlein purpura;    mesothelioma;    pleura;    renal failure;    vasculitis;   

DOI  :  10.1002/rcr2.78

来源: Wiley

【 摘 要 】

Abstract

Henoch–Schonlein purpura (HSP) is primarily a childhood immunoglobulin A (IgA)-mediated illness. When adults are affected, malignancy can be associated. We present a rare case of HSP in a 75-year-old man with malignant pleural mesothelioma. He presented with episodes of dizziness and subsequently developed non-palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment. HSP was diagnosed based on clinical and histological findings on biopsy specimens from the skin and kidney that showed a leukocytoclastic vasculitis and mesangioproliferative glomerulonephritis with IgA deposits, respectively. He was treated with high-dose oral steroids with resolution of the skin and renal manifestations of the disease. HSP is rare in adults but has been linked to cancers. This is the first report of HSP in a patient with known malignant pleural mesothelioma.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.