Niche adaptation by expansion and reprogramming of general transcription factors

Molecular Systems Biology

Serdar Turkarslan¹  David J Reiss¹  Goodwin Gibbins¹  Wan Lin Su¹  Min Pan¹  J Christopher Bare¹  Christopher L Plaisier¹ 

[1] Baliga Lab, Institute for Systems Biology, Seattle, WA, USA

关键词: evolution by gene family expansion;    fitness;    niche adaptation;    reprogramming of gene regulatory network;    transcription factor B;   

DOI  :  10.1038/msb.2011.87

来源: Wiley

【 摘 要 】

Numerous lineage-specific expansions of the transcription factor B (TFB) family in archaea suggests an important role for expanded TFBs in encoding environment-specific gene regulatory programs. Given the characteristics of hypersaline lakes, the unusually large numbers of TFBs in halophilic archaea further suggests that they might be especially important in rapid adaptation to the challenges of a dynamically changing environment. Motivated by these observations, we have investigated the implications of TFB expansions by correlating sequence variations, regulation, and physical interactions of all seven TFBs in Halobacterium salinarum NRC-1 to their fitness landscapes, functional hierarchies, and genetic interactions across 2488 experiments covering combinatorial variations in

【 授权许可】

CC BY-NC-SA   
Copyright © 2011 EMBO and Macmillan Publishers Limited

Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation without specific permission.