Protein localization as a principal feature of the etiology and comorbidity of genetic diseases

Molecular Systems Biology

Solip Park³  Jae-Seong Yang³  Young-Eun Shin¹  Juyong Park²  Sung Key Jang³ 

[1] Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea;Physics Department, Kyung Hee University, Seoul, Korea;School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea

关键词: cellular networks;    comorbidity;    human disease;    subcellular localization;   

DOI  :  10.1038/msb.2011.29

来源: Wiley

【 摘 要 】

Proteins targeting the same subcellular localization tend to participate in mutual protein–protein interactions (PPIs) and are often functionally associated. Here, we investigated the relationship between disease-associated proteins and their subcellular localizations, based on the assumption that protein pairs associated with phenotypically similar diseases are more likely to be connected via subcellular localization. The spatial constraints from subcellular localization significantly strengthened the disease associations of the proteins connected by subcellular localizations. In particular, certain disease types were more prevalent in specific subcellular localizations. We analyzed the enrichment of disease phenotypes within subcellular localizations, and found that there exists

【 授权许可】

CC BY-NC-SA   
Copyright © 2011 EMBO and Macmillan Publishers Limited

Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation without specific permission.