Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques

Molecular Systems Biology

Wan-Lin Su²  Robert R Kleinhanz¹ 

[1] Department of Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc., Seattle, WA, USA;Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA

关键词: causal associations;    eQTL mapping;    expression QTL;    microRNA;   

DOI  :  10.1038/msb.2011.23

来源: Wiley

【 摘 要 】

Integrative genomics and genetics approaches have proven to be a useful tool in elucidating the complex relationships often found in gene regulatory networks. More importantly, a number of studies have provided the necessary experimental evidence confirming the validity of the causal relationships inferred using such an approach. By integrating messenger RNA (mRNA) expression data with microRNA (miRNA) (i.e. small non-coding RNA with well-established regulatory roles in a myriad of biological processes) expression data, we show how integrative genomics approaches can be used to characterize the role played by approximately a third of registered mouse miRNAs within the context of a liver gene regulatory network. Our analysis reveals that the transcript abundances of miRNAs are subject to

【 授权许可】

CC BY-NC-SA   
Copyright © 2011 EMBO and Macmillan Publishers Limited

Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation without specific permission.