The functional diversity of protein lysine methylation

Molecular Systems Biology

Sylvain Lanouette¹  Vanessa Mongeon¹  Daniel Figeys¹ 

[1] Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada

关键词: lysine demethylation;    lysine methylation;    networks;    proteomics;    systems biology;   

DOI  :  10.1002/msb.134974

来源: Wiley

【 摘 要 】

Abstract

Large-scale characterization of post-translational modifications (PTMs), such as phosphorylation, acetylation and ubiquitination, has highlighted their importance in the regulation of a myriad of signaling events. While high-throughput technologies have tremendously helped cataloguing the proteins modified by these PTMs, the identification of lysine-methylated proteins, a PTM involving the transfer of one, two or three methyl groups to the ε-amine of a lysine side chain, has lagged behind. While the initial findings were focused on the methylation of histone proteins, several studies have recently identified novel non-histone lysine-methylated proteins. This review provides a compilation of all lysine methylation sites reported to date. We also present key examples showing the impact of lysine methylation and discuss the circuitries wired by this important PTM.

【 授权许可】

CC BY   
© 2014 The Authors. Published under the terms of the CC BY license.

Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.