Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni

MicrobiologyOpen

Axel Müller³  Morgan Beeby²  Alasdair W. McDowall¹  Janet Chow²  Grant J. Jensen² 

[1] Beckman Institute, California Institute of Technology, Pasadena, California;Division of Biology, California Institute of Technology, Pasadena, California;Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California

关键词: Acidocalcisomes;    Campylobacterales;    chemoreceptors;    cryoelectron tomography;    cryo‐EM;    food poisoning;    polyphosphate storage granules;   

DOI  :  10.1002/mbo3.200

来源: Wiley

【 摘 要 】

Abstract

Campylobacter jejuni is one of the most successful food-borne human pathogens. Here we use electron cryotomography to explore the ultrastructure of C. jejuni cells in logarithmically growing cultures. This provides the first look at this pathogen in a near-native state at macromolecular resolution (~5 nm). We find a surprisingly complex polar architecture that includes ribosome exclusion zones, polyphosphate storage granules, extensive collar-shaped chemoreceptor arrays, and elaborate flagellar motors.

【 授权许可】

CC BY   
© 2014 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.