Disposition of Extended Release Levetiracetam in Normal Healthy Dogs After Single Oral Dosing

Journal of Veterinary Internal Medicine

M.J. Beasley¹ 

[1] Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL

关键词: Anticonvulsants;    Antiepileptics;    Seizures;   

DOI  :  10.1111/jvim.13588

来源: Wiley

【 摘 要 】

Abstract

Background

Levetiracetam is an anticonvulsant used for control of canine epilepsy. An extended release preparation should improve dosing convenience.

Objectives

To determine the disposition of extended release levetiracetam in normal dogs after single dosing.

Animals

Pharmacokinetic study: 16 healthy, adult dogs.

Methods

Using a partially randomized crossover study, levetiracetam (30 mg/kg) was administered intravenously (IV) and orally (PO) as extended release preparation with or without food. Blood was collected for 24 hours (IV) or 36 hours (PO). Serum levetiracetam was quantitated by immunoassay and data were subjected to noncompartmental analysis.

Results

Pharmacokinetic parameters for fasted versus fed animals, respectively, were (mean ± SEM): C_max = 26.6 ± 2.38 and 30.7 ± 2.88 μ/mL, T_max = 204.3 ± 18.9 and 393.8 ± 36.6 minutes, t_1/2 = 4.95 ± 0.55 and 4.48 ± 0.48 hours, MRT = 9.8 ± 0.72 and 10 ± 0.64 hours, MAT = 4.7 ± 0.38 and 5.6 ± 0.67 hours, and F = 1.04 ± 0.04 and 1.26 ± 0.07%. Significant differences were limited to T_max (longer) and F (greater) in fed compared to fasted animals. Serum levetiracetam concentration remained above 5 μ/mL for approximately 20 hours in both fasted and fed animals.

Conclusions and Clinical Importance

Extended release levetiracetam (30 mg/kg q12h), with or without food, should maintain concentrations above the recommended minimum human therapeutic concentration.

【 授权许可】

CC BY-NC   
Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of American College of Veterinary Internal Medicine.

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