Natural History of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: A Prospective Study

Journal of Veterinary Internal Medicine

K.M. Meurs¹  J.A. Stern¹  Y. Reina-Doreste²  A.W. Spier¹  S.L. Koplitz¹ 

[1] The Ohio State University College of Veterinary Medicine, Columbus, OH;North Carolina State University College of Veterinary Medicine, Raleigh, NC

关键词: Boxer;    Holter;    Striatin;    Sudden death;    Ventricular premature complex;   

DOI  :  10.1111/jvim.12385

来源: Wiley

【 摘 要 】

Abstract

Background

Boxer arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease that may result in sudden death or heart failure.

Hypothesis/objectives

To prospectively study the natural history of Boxer ARVC.

Animals

72 dogs (49 ARVC, 23 controls).

Methods

Boxers >1 year of age were recruited for annual reevaluation. Controls were defined as being ≥6 years of age and having <50 ventricular premature complex (VPCs)/24 h. ARVC was defined as ≥300 VPCs/24 h in the absence of other disease. Dogs were genotyped for the striatin deletion when possible. Descriptive statistics were determined for age; VPC number; annual change in VPC number; and left ventricular (LV) echocardiographic dimensions. Survival time was calculated.

Results

Controls: median age of 7 years (range, 6–10); number of VPCs 12 (range, 4–32). Median time in study of 6 years (range, 2–9). Seventeen of 23 were genotyped (5 positive, 12 negative).

ARVC: median age of diagnosis of 6 (range, 1–11). Median time in study 5 years (range, 3–8). A total of 33% were syncopal and 43/49 were genotyped (36 positive, 7 negative). Yearly change in VPCs was 46 (range, −7,699 to 33,524). Annual percentage change in LV dimensions was 0, and change in fractional shortening (FS%) was 2%. Two dogs had FS% <20%. Although ARVC dogs died suddenly, there was no difference in survival time between groups. ARVC median age of survival was 11 years, and for controls was 10 years.

Conclusions/Clinical Importance

Arrhythmogenic right ventricular cardiomyopathy is a disease of middle age and frequently is associated with the striatin deletion. Syncope occurs in approximately 1/3 of affected dogs; systolic dysfunction is uncommon. The prognosis in many affected dogs is good.

【 授权许可】

Unknown   
Copyright © 2014 by the American College of Veterinary Internal Medicine