Cystatin C: A New Renal Marker and Its Potential Use in Small Animal Medicine

Journal of Veterinary Internal Medicine

L. Ghys²  D. Paepe²  P. Smets²  H. Lefebvre¹  J. Delanghe³ 

[1] Clinical Research Unit, National Veterinary School of Toulouse, Toulouse Cedex 3, France;Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Health Medicine and Life Sciences, Ghent University, Ghent, Belgium

关键词: Cat;    Dog;    Glomerular filtration rate;    Human;    Renal diseases;   

DOI  :  10.1111/jvim.12366

来源: Wiley

【 摘 要 】

Abstract

The occurrence of chronic kidney disease is underestimated in both human and veterinary medicine. Glomerular filtration rate (GFR) is considered the gold standard for evaluating kidney function. However, GFR assessment is time-consuming and labor-intensive and therefore not routinely used in practice. The commonly used indirect GFR markers, serum creatinine (sCr) and urea, are not sufficiently sensitive or specific to detect early renal dysfunction. Serum cystatin C (sCysC), a proteinase inhibitor, has most of the properties required for an endogenous GFR marker. In human medicine, numerous studies have evaluated its potential use as a GFR marker in several populations. In veterinary medicine, this marker is gaining interest. The measurement is easy, which makes it an interesting parameter for clinical use. This review summarizes current knowledge about cystatin C (CysC) in humans, dogs, and cats, including its history, assays, relationship with GFR, and biological and clinical variations in both human and veterinary medicine.

【 授权许可】

Unknown   
Copyright © 2014 by the American College of Veterinary Internal Medicine