A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy

Journal of Veterinary Internal Medicine

L.M. Freeman¹  J.E. Rush¹  S.M. Cunningham¹ 

[1]Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA

关键词: Cardiomyopathy;    Congestive heart failure;    Nutrition;   

DOI  :  10.1111/jvim.12352

来源: Wiley

【 摘 要 】

Abstract

Background

Diet might influence progression of hypertrophic cardiomyopathy (HCM).

Objective

To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM.

Animals

Twenty-nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital.

Methods

Randomized, placebo-controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months.

Results

There were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, P = .760; Group B, P = .475; Group C, P = .066) or interventricular septal thickness in diastole (Group A, P = .528; Group B, P = .221; Group C, P = .097). Group A had significant increases in BUN (P = .008) and cholesterol (P = .021), while Group B had significant increases in BUN (P = .008), cholesterol (P = .007), and triglycerides (P = .005), and significant decreases in NT-proBNP (P = .013) and hs-troponin I (P = .043). Group C had significant decreases in body weight (P = .021), left atrial dimension (P = .035), interventricular septal thickness in systole (P = .038), and liver enzymes (P = .034–.038).

Conclusions and Clinical Importance

These data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM.

【 授权许可】

Unknown   
Copyright © 2014 by the American College of Veterinary Internal Medicine