Levetiracetam Rectal Administration in Healthy Dogs

Journal of Veterinary Internal Medicine

R.K. Peters¹  T. Schubert¹  R. Clemmons¹ 

[1] Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL

关键词: Anticonvulsant;    Cluster;    Epilepsy;    Status;   

DOI  :  10.1111/jvim.12269

来源: Wiley

【 摘 要 】

Abstract

Background

Levetiracetam is used to manage status epilepticus (SE) and cluster seizures (CS) in humans. The drug might be absorbed after rectal administration and could offer a practical adjunct to rectal administration of diazepam in managing SE and CS.

Hypothesis

Levetiracetam is rapidly absorbed after rectal administration in dogs and maintains target serum concentrations for at least 9 hours.

Animals

Six healthy privately owned dogs between 2 and 6 years of age and weighing 10–20 kg.

Methods

Levetiracetam (40 mg/kg) was administered rectally and blood samples were obtained immediately before (time zero) and at 10, 20, 40, 60, 90, 180, 360, and 540 minutes after drug administration. Dogs were observed for signs of adverse effects over a 24-hour period after drug administration.

Results

C_LEV at 10 minutes was 15.3 ± 5.5 μg/mL (mean, SD) with concentrations in the target range (5–40 μg/mL) for all dogs throughout the sampling period. C_max (36.0 ± 10.7 μg/mL) and T_max (103 ± 31 minutes) values were calculated and 2 disparate groups were appreciated. Dogs with feces in the rectum at the time of drug administration had lower mean C_max values (26.7 ± 3.4 μg/mL) compared with those without (45.2 ± 4.4 μg/mL). Mild sedation was observed between 60 and 90 minutes without other adverse effects noted.

Conclusions and Clinical Importance

This study supports the use of rectally administered levetiracetam in future studies of clinical effectiveness in the management of epileptic dogs.

【 授权许可】

Unknown   
Copyright © 2014 by the American College of Veterinary Internal Medicine